dc.contributor.author | KELLEHER, DERMOT P | |
dc.contributor.author | MCMANUS, ROSS | |
dc.date.accessioned | 2009-10-07T10:06:48Z | |
dc.date.available | 2009-10-07T10:06:48Z | |
dc.date.issued | 2007 | |
dc.date.submitted | 2007 | en |
dc.identifier.citation | Azim K, McManus R, Brophy K, Ryan A, Kelleher D, Reynolds JV `Genetic Polymorphisms and the Risk of Infection Following Esophagectomy? in Annals of Surgery, 246, (1), 2007, pp 122 - 128 | en |
dc.identifier.other | Y | |
dc.identifier.uri | http://hdl.handle.net/2262/33806 | |
dc.description | PUBLISHED | en |
dc.description.abstract | OBJECTIVE: To examine the association of single nucleotide polymorphisms (SNPs) in inflammation-related genes in the development of infections following esophagectomy. SUMMARY BACKGROUND DATA: Genetic polymorphisms for immunoregulatory cytokines may explain individual variation in response to trauma. Esophagectomy is associated with a high risk of postoperative infection and sepsis, and this study explored a number of SNPs in cytokine genes and their relationship to postoperative infection. METHODS:: In a prospective analysis of 197 patients with esophageal cancer undergoing resection, 55 developed postoperative infections. DNA was extracted and genotyping was performed for polymorphisms in genes encoding TNF-alpha, IL-1beta, IL-1 receptor antagonist, IL-10, and Toll-like receptor 4 (TLR-4) using Taqman chemistry and PCR/RFLP. In a blinded analysis, the cohort with infections was compared with the no complication cohort (n = 114) and a cohort that had noninfective complications (n = 28). RESULTS: No differences in polymorphisms for IL-1beta, IL-1 RN, IL-10, and TLR-4 genes were observed across groups. The frequency of TNF-alpha -308 GG homozygotes was significantly (P = 0.021) higher in the postoperative infection group. The G allele was significantly higher in the postoperative infection group compared with the no complication group (P = 0.017) and other complication group (P = 0.013). By multivariate analysis, this polymorphism as well as age and body mass index were predictors of infection. CONCLUSION: The TNF-alpha -308A allele has been shown to be associated with higher circulating levels of TNF-alpha and the -308 G allele is a comparative low secretor allele. We propose that the polymorphism in the promotor region of TNF-alpha gene may lead to altered expression and a possible suboptimal activity of TNF-alpha in persons with GG genotypes, and these data suggest a link with infection following major surgery. | en |
dc.format.extent | 122 | en |
dc.format.extent | 128 | en |
dc.format.extent | 270738 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en | en |
dc.publisher | Lippincott Williams & Wilkins | en |
dc.relation.ispartofseries | Annals of Surgery | en |
dc.relation.ispartofseries | 246 | en |
dc.relation.ispartofseries | 1 | en |
dc.rights | Y | en |
dc.subject | Clinical Medicine | en |
dc.title | Genetic Polymorphisms and the Risk of Infection Following Esophagectomy | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/rmcmanus | |