Mouse and Pig Models for Studies of Natural and Vaccine-Induced Immunity to Bordetella pertussis.
Citation:
Mills KH, Gerdts V, Mouse and Pig Models for Studies of Natural and Vaccine-Induced Immunity to Bordetella pertussis., The Journal of infectious diseases, 209 Suppl 1, 2014, S16-9Download Item:
Abstract:
The increasing incidence of whooping cough in many developed countries has been linked with waning immu-
nity induced after immunization with acellular pertussis (aP) vaccines. The rational design of an improved aP
vaccine requires a full understanding of the mechanism of protective immunity and preclinical studies in
animal models. Infection of mice and pigs with
Bordetella pertussis
has many features of the infection seen in
humans and has already provided valuable information on the roles of innate and adaptive immune responses
in protection. Recent
findings in these models have already indicated that it may be possible to develop an improved aP vaccine based on a formulation that includes a Toll-like receptor agonist as an adjuvant
Author's Homepage:
http://people.tcd.ie/millskDescription:
PUBLISHED
Author: MILLS, KINGSTON
Type of material:
Journal ArticleCollections
Series/Report no:
The Journal of infectious diseases209 Suppl 1
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Full text availableKeywords:
adjuvant, Tcells, protective immunity, vaccine, respiratory infection, animal model;, whooping cough, Bordetella pertussisSubject (TCD):
Immunology, Inflammation & InfectionDOI:
http://dx.doi.org/10.1093/infdis/jit488Metadata
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