dc.contributor.author | SAUNDERS, SEAN | en |
dc.contributor.author | FALLON, PADRAIC | en |
dc.contributor.author | DONNELLY, SEAMAS | en |
dc.date.accessioned | 2014-11-26T15:26:07Z | |
dc.date.available | 2014-11-26T15:26:07Z | |
dc.date.issued | 2014 | en |
dc.date.submitted | 2014 | en |
dc.identifier.citation | Hams E, Armstrong ME, Barlow JL, Saunders SP, Schwartz C, Cooke G, Fahy RJ, Crotty TB, Hirani N, Flynn RJ, Voehringer D, McKenzie AN, Donnelly SC, Fallon PG, IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis., Proceedings of the National Academy of Sciences of the United States of America, 111, 1, 2014, 367-72 | en |
dc.identifier.other | Y | en |
dc.identifier.uri | http://hdl.handle.net/2262/72201 | |
dc.description | PUBLISHED | en |
dc.description.abstract | Disease conditions associated with pulmonary fibrosis are progressive and have a poor long-term prognosis with irreversible changes in airway architecture leading to marked morbidity and mortalities. Using murine models we demonstrate a role for interleukin (IL)-25 in the generation of pulmonary fibrosis. Mechanistically, we identify IL-13 release from type 2 innate lymphoid cells (ILC2) as sufficient to drive collagen deposition in the lungs of challenged mice and suggest this as a potential mechanism through which IL-25 is acting. Additionally, we demonstrate that in human idiopathic pulmonary fibrosis there is increased pulmonary expression of IL-25 and also observe a population ILC2 in the lungs of idiopathic pulmonary fibrosis patients. Collectively, we present an innate mechanism for the generation of pulmonary fibrosis, via IL-25 and ILC2, that occurs independently of T-cell-mediated antigen-specific immune responses. These results suggest the potential of therapeutically targeting IL-25 and ILC2 for the treatment of human fibrotic diseases. | en |
dc.format.extent | 367-72 | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Proceedings of the National Academy of Sciences of the United States of America | en |
dc.relation.ispartofseries | 111 | en |
dc.relation.ispartofseries | 1 | en |
dc.rights | Y | en |
dc.subject | therapy | en |
dc.subject | innate response | en |
dc.subject | inflammation | en |
dc.subject | cytokine | en |
dc.title | IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis. | en |
dc.type | Journal Article | en |
dc.type.supercollection | scholarly_publications | en |
dc.type.supercollection | refereed_publications | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/saundes | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/pfallon | en |
dc.identifier.peoplefinderurl | http://people.tcd.ie/sdonnel1 | en |
dc.identifier.rssinternalid | 95791 | en |
dc.identifier.doi | http://dx.doi.org/10.1073/pnas.1315854111 | en |
dc.rights.ecaccessrights | openAccess | |
dc.subject.TCDTheme | Immunology, Inflammation & Infection | en |
dc.subject.TCDTag | Biomedical sciences | en |
dc.identifier.orcid_id | 0000-0003-1689-3598 | en |