The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic environments
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2015Author:
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Phelan JJ, O Hanlon C, Reynolds JV and O Sullivan J, The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic environments, Gastro., 1, 2, 2015, 44 - 58Abstract:
Cellular
metabolism
plays
a
crucial
role
in
primed
inflammatory,
hypoxic
and
an
-
giogenic microenvironments by supporting disease progression in a range of disease entities.
To
adapt
to
fluctuating
stress-induced
microenvironments,
pre-neoplastic
and
neoplastic
tissue
must
utilise
a
diverse
range
of
molecular
mediators
to
alter
their
metabolism.
Despite
being
widely
documented
to
play
independent
roles
in
disease
prevalence,
these
complex
processes
exploit
a
range
of
key
cellular
components
that
act
in
tandem
to
restore
metabolic
equilibrium.
Therefore,
this
review
examines
the
primary
molecular
mechanisms
linking
energy
metabolism
with
inflammation,
hypoxia
and
angiogenesis.
Furthermore,
the
review
considers
a
diverse
range
of
conventional
and
novel
mediators
that
link
energy
metabolism
and
hypoxia.
More
-
over,
to
investigate
their
reciprocal
relationship
and
the
mechanisms
employed
to
execute
their
functional
effect
in
greater
detail,
the
roles
of
glycolysis
and
oxidative
phosphorylation
in
rheu
-
matoid
arthritis
and
circadian
rhythms
respectively
are
reviewed.
Lastly,
this
review
explores
some
current
metabolic-based
treatments
and
multi-targeted
therapies
that
could
potentially
target
these
fundamental
cellular
processes.
Author's Homepage:
http://people.tcd.ie/osullij4Description:
PUBLISHED
Author: O'SULLIVAN, JACINTHA
Type of material:
Journal ArticleCollections
Series/Report no:
Gastro.1
2
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Full text availableKeywords:
Energy metabolism, Inflammation, Hypoxia, AngiogenesisMetadata
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