dc.contributor.advisor | Sheils, Orla | |
dc.contributor.author | Flavin, Richard | |
dc.date.accessioned | 2017-01-18T16:30:08Z | |
dc.date.available | 2017-01-18T16:30:08Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Richard Flavin, 'The role of activated RET in papillary tumour morphogenesis', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2011, pp 219 | |
dc.identifier.other | THESIS 9230 | |
dc.identifier.uri | http://hdl.handle.net/2262/78986 | |
dc.description.abstract | RET/PTC rearrangements are initiating events in the development of a significant proportion of papillary thyroid carcinomas. Activated RET/PTC mutations are thought to be restricted to thyroid disease, but in this study we propose that these events maybe features of papillary morphology. 57 non-thyroid papillary tumours were examined for RET/PTC rearrangements using interphase FISH, Taqman™ RT-PCR and immunohistochemistry. 20% (3/15) of primary peritoneal carcinoma had detectable RET/PTC] rearrangements by all three methodologies. A further case of similar histotype had an alternate RET/PTC rearrangement. No RET/PTC1 rearrangements were detected in the remaining tumour cohort. Our results indicate that RET/PTC rearrangements occur in a small subset of non-thyroid papillary tumours. These rearrangements may not be directly implicated in tumour growth; rather representing ‘passenger’ mutations reflecting RET instability in secondary tumour subclones. | |
dc.format | 1 volume | |
dc.language.iso | en | |
dc.publisher | Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy | |
dc.relation.isversionof | http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb14642880 | |
dc.subject | Histopathology and Morbid Anatomy, M.D. | |
dc.subject | M.D. Trinity College Dublin | |
dc.title | The role of activated RET in papillary tumour morphogenesis | |
dc.type | thesis | |
dc.type.supercollection | thesis_dissertations | |
dc.type.supercollection | refereed_publications | |
dc.type.qualificationlevel | Bachelor of Science | |
dc.type.qualificationname | Doctor of Medicine (M.D.) | |
dc.rights.ecaccessrights | openAccess | |
dc.format.extentpagination | pp 219 | |
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