Browsing Histopathology & Morbid Anatomy (Theses and Dissertations) by Date of Publication
Now showing items 1-20 of 44
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Prognostic markers in thyroid neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2000)Prognosis in thyroid carcinoma is usually assessed on the basis of criteria, which include patient age and histological type, grade and stage of tumour. It is well recognised, however, that while occasional tumours with ... -
Molecular analysis of Human Herpes Virus 8 and associated lesions
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2003)This thesis looks at the bio-pathways of HHV8 through the transformation of endothelial cell lines. This was performed in two separate but mutually contributing experiments. First, endothelial cell lines were infected using ... -
C-ABL in human cancer: an investigation of its role in apoptosis inhibition, differentiation and angiogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2003)Research over the past number of decades has significantly advanced our understanding of the cell signalling effects that mediate a diverse array of cellular activities including cell proliferation, homeostasis and ... -
Molecular characterisation of a new variant of inflammatory bowel disease in children with autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2004)A new variant of inflammatory bowel disease, provisionally termed "autistic enterocolitis" has been described in a cohort of children with autistic spectrum disorders. The intestinal pathology includes ileo-colonic ... -
Molecular markers in cervical cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2004)Despite the introduction of the Papanicolaou (Pap) test carcinoma of the cervix remains one of the most common malignancies amongst women worldwide. It is hoped that the use of HPV testing and molecular biomarkers in ... -
Molecular algorithms in thyroid neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2005)Papillary thyroid carcinoma is the most comm on thyroid malignancy, with an incidence of <100 cases per year in Ireland and 16,000 cases per year in the U.S. Incidence is increasing with a global estimate of half a million ... -
Genome wide investigation of papillary thyroid carcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2005)In recent years, there has been a technological explosion in the fields of molecular pathology and molecular oncology. The genome, transcriptome and increasingly the proteome of diverse tumours can now be analysed in minute ... -
Investigation of oral and oropharyngeal squamous cell carcinoma in young adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2006)While oral and pharyngeal squamous cell carcinoma is classically a disease of older male smokers, this tumour type can occur in young patients with minimal or no exposure to the traditional risk factors. The prognosis ... -
Molecular signatures in papillary thyroid carcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2007)Papillary thyroid carcinomas (PTC) are the most frequently occurring type of thyroid malignancy (85%-90%). PTC affects females more frequently than males, with a ratio of 3:1 and can be present in any age group, the mean ... -
Molecular signatures of prostate cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2008)Prostate cancer is the second most common cancer in Irish men and the second most common cause of cancer-related deaths. In the United States, there are approximately 234,000 new cases diagnosed every year and 27,350 deaths. ... -
Identification of novel biomarkers in recurrent / chemoresistant ovarian cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)The aim of this study was to identify novel biomarkers in recurrent/chemoresistant ovarian cancer, yet an incurable disease. Using cDNA microarrays, we identified distinct patterns of gene expression between primary and ... -
Molecular gene and regulatory profiles in thyroid cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Thyroid carcinoma is the most common endocrine malignancy, with an incidence of approximately eighty cases per year in Ireland and thirty seven thousand cases per year in the United States. While thyroid cancer may be ... -
Molecular algorithms in ovarian serous neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Epithelial ovarian cancer is one of the most common cancers in women and the leading cause of death from gynaecological malignancy in the western world. Approximately 205,000 cases of ovarian cancer are diagnosed worldwide ... -
Cancer stemness : unravelling the molecular mechanisms controlling stem cell differentiation and self-renewal
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Understanding the molecular mechanisms behind cancer cell proliferation and regulation is the key to discovering potential future successful therapies for cancer. The World Health Organisation estimates that 7.6 million ... -
Development of extraction and analysis of protocols for RNA in formalin-fixed paraffin-embedded (FFPE) materials using TaqMan® real-time PCR
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Archival Formalin-Fixed, Paraffin-Embedded (FFPE) tissue samples represent an invaluable source of human tissue for gene expression analysis. They are the most abundant and readily available materials and generally well ... -
The expression and function of miRNAs in thyroid neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer deaths each year. Carcinomas of the thyroid comprise a heterogeneous group of neoplasms with distinctive clinical and ... -
The p16INK4A pathway in cervical cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)The p16INK4A protein has been proposed as a biomarker in cervical cancer and pre-cancer. p16INK4A over expression is in contrast to that seen in other cancers, where locus deletion or mutation is the norm. p16INK4A is ... -
Differential expression of differentation, key stemness and pathways genes and microRNAs and the role of Tgf-β in embryonal carinoma stem cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)Cancer stem cells (CSCs) identified in multiple malignancies has fuelled the belief that they drive primary tumourigenesis. Their persistence post-intervention contributes to metastasis, recurrence, self-renewal, thus ... -
Molecular targeting of HPV oncogenes and oncogenic protein
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)Worldwide cervical cancer is the second most common cause of cancer related death in women. Over the last three decades high-risk HPV has been conclusively established as the major etiological factor in cervical cancer and ... -
The role of activated RET in papillary tumour morphogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2011)RET/PTC rearrangements are initiating events in the development of a significant proportion of papillary thyroid carcinomas. Activated RET/PTC mutations are thought to be restricted to thyroid disease, but in this study ...
