| dc.contributor.author | Reynolds, John | |
| dc.contributor.author | Long, Aideen | |
| dc.contributor.author | Duggan, Shane P. | |
| dc.contributor.author | Garry, Catherine | |
| dc.contributor.author | Behan, Fiona | |
| dc.contributor.author | Phipps, Sinead | |
| dc.contributor.author | Kudo, Hiromi | |
| dc.contributor.author | Kirca, Murat | |
| dc.contributor.author | Zaheer, Abdul | |
| dc.contributor.author | McGarrigle, Sarah | |
| dc.contributor.author | Goldin, Robert | |
| dc.contributor.author | Kalloger, Steve E. | |
| dc.contributor.author | Schaeffer, David F. | |
| dc.contributor.author | Strid, Jessica | |
| dc.contributor.author | Kelleher, Dermot | |
| dc.date.accessioned | 2019-11-21T13:16:46Z | |
| dc.date.available | 2019-11-21T13:16:46Z | |
| dc.date.issued | 2018 | |
| dc.date.submitted | 2018 | en |
| dc.identifier.citation | Duggan, S.P., Garry, C., Behan, F.M., Phipps, S., Kudo, H., Kirca, M., Zaheer, A., McGarrigle, S., Reynolds, J.V., Goldin, R., Kalloger, S.E., Schaeffer, D.F., Long, A., Strid, J. & Kelleher, D., siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth, Cellular and Molecular Gastroenterology and Hepatology, 5, 4, 2018, 569-590 | en |
| dc.identifier.other | Y | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S2352345X18300195?via%3Dihub | |
| dc.identifier.uri | http://hdl.handle.net/2262/90819 | |
| dc.description.abstract | This study de
fi
nes immune-associated factors supportive of
esophageal adenocarcinoma cell growth through small
interfering RNA screening and pathologic and functional
studies. Fostamatinib R788, targeting Janus kinase/signal
transducer-and-activator of transcription and TYRO protein
tyrosine kinase binding protein/spleen tyrosine kinase/AKT
serine-threonine kinase pathways, induced esophageal
adenocarcinoma cell death and reduced tumor burden in
xenografted mice. | en |
| dc.format.extent | 569-590 | en |
| dc.language.iso | en | en |
| dc.relation.ispartofseries | Cellular and Molecular Gastroenterology and Hepatology; | |
| dc.relation.ispartofseries | 5; | |
| dc.relation.ispartofseries | 4; | |
| dc.rights | Y | en |
| dc.subject | Immune-associated factors | en |
| dc.subject | Esophageal Adenocarcinoma | en |
| dc.subject | Barrett's esophagus | en |
| dc.subject | Inflammation | en |
| dc.subject | Therapeutic targets | en |
| dc.title | siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth | en |
| dc.type | Journal Article | en |
| dc.type.supercollection | scholarly_publications | en |
| dc.type.supercollection | refereed_publications | en |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/longai | |
| dc.identifier.peoplefinderurl | http://people.tcd.ie/reynoljv | |
| dc.identifier.rssinternalid | 191399 | |
| dc.identifier.doi | http://dx.doi.org/10.1016/j.jcmgh.2018.01.012 | |
| dc.rights.ecaccessrights | openAccess | |
| dc.identifier.orcid_id | 0000-0002-9918-9960 | |
