Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease
Citation:
Healy C, Munoz-Wolf N, Strydom J, Faherty L, Williams NC, Kenny S, Donnelly SC, Cloonan SM. Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease, Respiratory Research, 2021 Apr 29;22(1):133Download Item:
Abstract:
Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and copper by the host to limit pathogenicity by invading microorganisms. As one of the most conserved activities of the innate immune sys‑tem, limiting the availability of free trace metals by cells of the immune system serves not only to conceal these vital nutrients from invading bacteria but also operates to tightly regulate host immune cell responses and function.In the setting of chronic lung disease, the regulation of trace metals by the host is often disrupted, leading to the altered availability of these nutrients to commensal and invading opportunistic pathogenic microbes. Similarly, alterations in the uptake, secretion, turnover and redox activity of these vitally important metals has significant repercussions for immune cell function including the response to and resolution of infection. This review will discuss the intricate role of nutritional immunity in host immune cells of the lung and how changes in this fundamental process as a result of chronic lung disease may alter the airway microbiome, disease progression and the response to infection.
Sponsor
Grant Number
Science Foundation Ireland
Future Research Leaders Grant FRL4862
Author's Homepage:
http://people.tcd.ie/cloonas
Author: Cloonan, Suzanne
Type of material:
Journal ArticleCollections
Series/Report no:
Respiratory Research;22;
1;
Availability:
Full text availableKeywords:
Nutritional immunity, Mycobacteria, Asthma, COPD, IPF, Immunity, Iron, Metals, MicrobiomeDOI:
http://dx.doi.org/10.1186/s12931-021-01722-yMetadata
Show full item recordLicences: