Browsing by Subject "Biochemistry & Immunology, Ph.D."
Now showing items 21-40 of 59
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Immunomodulatory properties of endogenous danger signals
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)The 'danger model' proposes that dying cells release specific endogenous molecules into the extracellular milieu following loss of plasma membrane integrity. This model postulates that these endogenous molecules, referred ... -
Immunotherapeutics & vaccine adjuvants for cancer
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)It is well established that innate immune responses not only mediate immunity to infection, but also promotes adaptive immunity to pathogens and tumours. Dendritic cells (DC) play a critical role as antigen presenting cells ... -
In Vitro screening of novel compounds to assess their potential as anti-cancer, biological imaging and anti-inflammatory agents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Gold nanoparticles (AuNps) are some of the most extensively studied nanomaterials. Because of their biocompatibility, unique size- and shape- dependence, optoelectronic and catalytic properties, AuNps have attracted enormous ... -
Indentification and functionality of antigens reacting with antisperm antibodies and their role in male immunoinfertility
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Antisperm antibodies (ASA) are a leading cause of male associated infertility. The male partner of 1 in 10 couples tests positive for sperm bound antibodies with immunoglobulins of the IgG class being found in all patients ... -
Induction of regulatory immune responses that control autoimmune diseases
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Regulatory T (Treg) cells play a fundamental role in suppressing excessive inflammatory responses to pathogens and in maintaining peripheral tolerance to self-antigens. A breakdown in self-tolerance or defect in Treg cells ... -
Interferon lambda, dendritic cells and Hepatitis C virus infection
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)It is estimated that ~3% of the world's population is infected with Hepatitis C virus (HCV), a hepatotropic virus which can lead to liver fibrosis, cirrhosis and hepatocellular carcinoma. Of those infected, ~20% clear the ... -
Investigating the role of inflammatory caspases during disease-associated inflammation
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes such as inflammation and apoptosis. Functional mechanisms surrounding the activation and signalling pathways mediated by ... -
Investigation of the oxidative folding pathway in Trypanosoma brucei
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)In eukaryotic organisms the native structure of proteins destined to be secreted, such as immunoglobulins, or mounted surface proteins rely on the formation of disulphide bridges between cysteine residues for structural ... -
Manipulating regulatory responses in antitumour immunity
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011)The immune system has evolved tolerogenic and regulatory mechanism to control responses to self-antigens and to ensure that the inflammatory immune response to pathogens does not cause excessive tissue damage during ... -
MicroRNA regulation of the bovine mammary immune response to a mastitis pathogen
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Bovine mastitis is an inflammation-driven disease of the mammary gland that is associated with €2 billion in yearly losses to the European dairy industry. Streptococcus uberis is now ranked amongst the most prevalent ... -
Natural killer cells in the Irish : investigating receptor expression and potential role in psoriasis
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)NK cells are granular lymphocytes which act as part of the innate immune system. Their activity is controlled through a balance of signals from inhibitory and activating receptors, with one important family of receptors ... -
Novel Peroxisome Proliferating Activated Receptor (PPAR) modulator drug discovery : consensus virtual screening and characterisation of biochemcial and pharmacological activities
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)Peroxisome proliferator-activated receptors (PPARs) are ligand activated transcription factors that form a subfamily of the nuclear receptor superfamily. PPARs form heterodimers with the 9-cis-retinoic acid receptor (RXR) ... -
Regulation of innate and adaptive immunity by the vaccine adjuvant alum
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)While many licensed vaccines consist of whole or inactivated pathogens, there is a move toward vaccines based on purified antigens which although safer are generally less immunogenic and therefore require adjuvants to ... -
Regulation of the immunomodulatory cytokine IL-10 by Twist2
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2014)Dysregulation of cytokines can lead to infectious and inflammatory diseases. The anti-inflammatory cytokine IL-10 is known to control pro-inflammatory cytokines such as TNF-a, IL-6 and IL-12. The regulation of IL-10 is ... -
Role of infection and T cells in disease pathogenesis in a model of Alzheimer's disease
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2015)Alzheimer's disease (AD) is a progressive neurodegenerative disease characterised by deposits of amyloid-β (Aβ) and neurofibrillary tangles. It has been suggested that inflammatory changes are associated with disease, ... -
Ruthenium(11) metal complexes for photodynamic therapy (PDT) or as imaging agents
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Photodynamic therapy (PDT) represents a new localised method of treatment in cancer. The therapeutic effect is mediated by the generation of reactive oxygen species (ROS) and/or the formation of singlet oxygen (1 O2), a ... -
SOCS3 regulation by microRNAs, cytokines and HCV
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2012)The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is the principal signalling mechanism for a wide array of cytokines. Dysregulation of JAK-STAT pathway has been noted in cancer and chronic ... -
Sterol regulatory element binding protein is a crucial regulator of natural killer cell metabolism and function
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2016)Natural Killer (NK) cells are a lymphocyte subset that has a key role in anti-viral and anti-tumour immunity. While the concept of immunometabolism has recently been recognised as critical in determining functions of immune ... -
Structural and functional characterisation of a novel bovine β-defensin gene cluster
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)Antimicrobial peptides (AMPs) have been characterised by their ability to neutralise pathogens directly by disrupting their membranes. Recently described roles for these peptides include chemotactic activity, wound healing ... -
Structural and functional studies of a turmour killing protein-fatty acid complex
(Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2013)HAMLET (Human Alpha-lactalbumin Made LEthal to Tumour cells) is a complex between the milk protein a-lactalbumin (a-LA) and a fatty acid, oleic acid (OA), and displays remarkable properties of selectively killing tumour ...