Browsing Histopathology & Morbid Anatomy (Theses and Dissertations) by Date of Publication
Now showing items 21-40 of 44
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Human papillomavirus prevalence in the Irish cervical screening population and a specific group of HIV positive women
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2011)Human Papillomavirus (HPV) is the major aetiological agent in the development of cervical pre-cancer and cancer with high-risk HPV (HR-HPV) types 16 and 18 detected in greater than 70% of squamous cell carcinomas of the ... -
Developing novel therapeutic approaches in chemoresistant ovarian cancer patients
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Ovarian cancer is the fifth most common cause of cancer death in women and is the leading cause of death from gynaecological malignancy in the Western world. A recent study by the National Cancer Registry, Ireland has shown ... -
Cancer cell-platelet interactions in ovarian cancer metastasis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Ovarian cancer is the leading cause of death from gynaecological malignancy worldwide with an estimated global incidence of 225,900 and mortality of 140,200 per year. In Ireland ovarian cancer is the second most common ... -
HPV mRNA and p16[ink4a] / Ki-67 detection for improved diagnosis and management of cervical neoplasia in smokers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Persistent infection with high risk human papillomavirus (HR HPV) is the main etiological agent in the development of cervical cancer. The use of HPV DNA testing in cervical screening programs is becoming increasingly ... -
MicroRNA profiling in prostate cancer and prostate derived holoclone cell model
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Prostate cancer is a heterogeneous disease and is the most commonly diagnosed malignant tumour and the second most common cause of cancer deaths in western males. Prostate cancer is the most commonly diagnosed cancer in ... -
Regulation of cancer stem cell differentiation by genes and microRNAs
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Since the discovery of a stem cell phenotype in cancer, specific tumour cells with this phenotype, often called cancer stem cells (CSCs), are now widely accepted as the progenitors of oncogenesis, proliferation, treatment ... -
Non-coding RNA expression in cancer stem cell progenies derived from tumours +/-BRAF V600E mutation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Cancer has placed a huge burden on the global health system and rising rates in particular cancer types such as lung cancer and melanoma due to smoking and increased UV ray exposure respectively has highlighted the need ... -
Identification, isolation and validation of ovarian cancer stem cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Ovarian cancer is often diagnosed at a late stage. Even so, it often responds (~73 %) to first-line therapies. However, the five year survival rate for late stage ovarian cancer is poor (~27 %). It is hypothesised that ... -
Diagnostic and prognostic biomarkers in ovarian cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Ovarian cancer is the fifth most common cancer in women and the most frequent cause of gynaecological malignancy-related mortality in women. The vast majority present in advanced stages and this is due to lack of a reliable ... -
Investigation of autoantibody profiling to reveal biomarkers of ovarian cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Ovarian cancer is the most deadly gynaecological malignancy and 70% of all women with ovarian cancer die within 5 years of diagnosis. When diagnosed in early stages, ovarian cancer is curable in 90% of cases, however early ... -
Post-transcriptional Dysregulation by microRNAs is implicated in the Pathogenesis of Gastrointestinal Stromal Tumour [GIST]
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)In a cohort of 73 GISTs including adult mutant, adult wild-type and paediatric cases miRNA expression was examined using TaqMan® Low Density Arrays (TLDAs), allowing the profiling of 667 miRNAs in a set of two (pool A and ... -
MyD88 : a key regulator of chemoresistance, differentiation and hypoxia resistance in cancer stem cells?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Ovarian cancer, the leading cause of gynaecologic cancer deaths in the western world is characterised by high rates of chemoresistant recurrence. While in primary cases, differentiation status of the tumour is considered ... -
The silencing of HPV16 Oncogenes using E6siRNAs
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2014)Cervical cancer is the fourth most common cancer worldwide and remains a rising cause of cancer deaths amongst women worldwide, particularly in low to mid-income countries. High risk HPV is the main etiological factor in ... -
Molecular features of aggressive prostate carcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015)Prostate cancer is the most common form of malignancy in the male urinary tract and accounts for more than 20% of all newly diagnosed male cancer cases. The vast majority of prostate tumours are clinically insignificant, ... -
The role of MyD88 in embryonal carcinoma stem cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015)Tumour-initiating cells are known to share some properties with stem cells. These so called 'Cancer Stem Cells' (CSCs) are highly tumourigenic in the undifferentiated state, a property that is lost upon CSC differentiation. ... -
Platinum and taxane chemoresistance mechanisms in ovarian cancer cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015)Ovarian cancer is the leading cause of death from a gynaecological malignancy, typically presenting at late stage due to difficult diagnosis and lack of suitable screening tools. The standard treatment of combination ... -
A therapeutic roadmap for ovarian cancer using TLR4 MyD88 and MAD2 as prognostic indicators
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2016)Ovarian cancer is 4th leading cause of cancer death in woman and the most lethal gynaecological malignancy. Most patients present with advanced disease where the 5 year survival rate is less than 40%. Standard treatment ... -
Molecular Mechanisms of Advanced Prostate Cancer
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2018)Globally, prostate cancer is the fourth most common cancer type. Five year survival rates for primary localised disease are high, however these figures decrease significantly with the onset of metastasis. Obesity and ... -
ECHO: the epidemiology of HPV infection in oropharyngeal, oral cavity, and laryngeal cancer in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2019)Human Papillomavirus (HPV) infection has been identified as a significant etiological agent in the development of head and neck squamous cell carcinoma (HNSCC). There is mounting evidence from North America and Europe to ... -
The use of nanotechnology for treatment of multidrug resistant ovarian cancer cells
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2019)The traditional ovarian cancer treatment includes a combination of surgery and chemotherapy. However, the prognosis for ovarian cancer following treatment is very poor in the majority of ovarian cancer patients, especially ...
