The role of MyD88 in embryonal carcinoma stem cells
Citation:
Gomaa M. A. Sulaiman, 'The role of MyD88 in embryonal carcinoma stem cells', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015, pp 177Download Item:
Abstract:
Tumour-initiating cells are known to share some properties with stem cells. These so
called 'Cancer Stem Cells' (CSCs) are highly tumourigenic in the undifferentiated
state, a property that is lost upon CSC differentiation. For many years, our group has
studied CSC differentiation in a nullipotent embryonal carcinoma CSC cell line
(2102Ep), which can resist differentiation to produce highly-aggressive tumours.
Previous work in the lab highlighted a potential role for Toll-Like Receptor (TLR)
Signaling mediator protein Myeloid Differentiation Response Gene 88 (MyD88) in the
mechanism through which 2102Ep cells resist differentiation.
Author: Sulaiman, Gomaa M. A.
Advisor:
O'Leary, JohnQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid AnatomyNote:
TARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ieType of material:
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