The role of MyD88 in embryonal carcinoma stem cells

Sulaiman, Gomaa M. A.

dc.contributor.advisor	O'Leary, John
dc.contributor.author	Sulaiman, Gomaa M. A.
dc.date.accessioned	2019-11-14T14:55:44Z
dc.date.available	2019-11-14T14:55:44Z
dc.date.issued	2015
dc.identifier.citation	Gomaa M. A. Sulaiman, 'The role of MyD88 in embryonal carcinoma stem cells', [thesis], Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015, pp 177
dc.identifier.other	THESIS 11177
dc.identifier.uri	http://hdl.handle.net/2262/90619
dc.description.abstract	Tumour-initiating cells are known to share some properties with stem cells. These so called 'Cancer Stem Cells' (CSCs) are highly tumourigenic in the undifferentiated state, a property that is lost upon CSC differentiation. For many years, our group has studied CSC differentiation in a nullipotent embryonal carcinoma CSC cell line (2102Ep), which can resist differentiation to produce highly-aggressive tumours. Previous work in the lab highlighted a potential role for Toll-Like Receptor (TLR) Signaling mediator protein Myeloid Differentiation Response Gene 88 (MyD88) in the mechanism through which 2102Ep cells resist differentiation.
dc.format	1 volume
dc.language.iso	en
dc.publisher	Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy
dc.relation.isversionof	http://stella.catalogue.tcd.ie/iii/encore/record/C__Rb16906398
dc.subject	Histopathology & Morbid Anatomy, Ph.D.
dc.subject	Ph.D. Trinity College Dublin.
dc.title	The role of MyD88 in embryonal carcinoma stem cells
dc.type	thesis
dc.type.supercollection	thesis_dissertations
dc.type.supercollection	refereed_publications
dc.type.qualificationlevel	Doctoral
dc.type.qualificationname	Doctor of Philosophy (Ph.D.)
dc.rights.ecaccessrights	openAccess
dc.format.extentpagination	pp 177
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