Browsing Histopathology & Morbid Anatomy (Theses and Dissertations) by Title
Now showing items 39-44 of 44
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The expression and function of miRNAs in thyroid neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)Thyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer deaths each year. Carcinomas of the thyroid comprise a heterogeneous group of neoplasms with distinctive clinical and ... -
The p16INK4A pathway in cervical cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)The p16INK4A protein has been proposed as a biomarker in cervical cancer and pre-cancer. p16INK4A over expression is in contrast to that seen in other cancers, where locus deletion or mutation is the norm. p16INK4A is ... -
The role of activated RET in papillary tumour morphogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2011)RET/PTC rearrangements are initiating events in the development of a significant proportion of papillary thyroid carcinomas. Activated RET/PTC mutations are thought to be restricted to thyroid disease, but in this study ... -
The role of MyD88 in embryonal carcinoma stem cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2015)Tumour-initiating cells are known to share some properties with stem cells. These so called 'Cancer Stem Cells' (CSCs) are highly tumourigenic in the undifferentiated state, a property that is lost upon CSC differentiation. ... -
The silencing of HPV16 Oncogenes using E6siRNAs
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2014)Cervical cancer is the fourth most common cancer worldwide and remains a rising cause of cancer deaths amongst women worldwide, particularly in low to mid-income countries. High risk HPV is the main etiological factor in ... -
The use of nanotechnology for treatment of multidrug resistant ovarian cancer cells
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2019)The traditional ovarian cancer treatment includes a combination of surgery and chemotherapy. However, the prognosis for ovarian cancer following treatment is very poor in the majority of ovarian cancer patients, especially ...