Browsing Clinical Medicine by Date of Publication
Now showing items 1-20 of 949
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Deriving a useful packed cell volume estimate from haemoglobin analysis
(1994)A method is described whereby the packed cell volume (PCV) of a blood sample can be estimated from the haemoglobin concentration. The method defines the relation existing between haemoglobin concentration and the PCV of ... -
Alterations in cytochrome-c oxidase expression between praziquantel-resistant and susceptible strains of Schistosoma mansoni.
(1998)The genetic differences between praziquantel-resistant (R) and susceptible (S) strains of Schistosoma mansoni (Fallon & Doenhoff, 1994) were explored using RAPD and by cloning differentially expressed mRNAs by subtractive ... -
Simultaneous disruption of Interleukin (IL)-4 and IL-13 defines individual roles in T Helper cell Type 2-mediated responses
(The Rockefeller University Press, 1999)Using a single vector targeting strategy, we have generated mice with a combined deficiency of interleukin (IL)-4 and IL-13 to clarify their roles in T helper type 2 (Th2) cell responses. Using immunological challenges ... -
Homocysteine, folate enzymes and neural tube defects
(1999)Background: The purpose of this study was to characterize total homocysteine (tHcy) levels at birth in preterm and term infants and identify associations with intraventricular hemorrhage (IVH) and other neonatal outcomes ... -
The "thermolabile" variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother
(1999)Recent reports have implicated the "thermolabile" (T) variant of methylenetetrahydrofolate reductase (MTHFR) in the causation of folate-dependent neural tube defects (NTDs). We report herein the largest genetic study of ... -
Particulate air pollution and mortality in Dublin 1980-1996
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Air pollution in Dublin was studied for the period from 1980 to 1996. The factors which contribute to air pollution were investigated, and the nature of particulate air pollution is discussed. The trends in air pollution, ... -
Nutritional and metabolic aspects of n-3 polyunsaturated fatty acids in health and disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)The health benefits of fish oils, rich in the n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are multi-faceted, spanning a number of human systems, including the cardiovascular, ... -
Tools and techniques for improving the assessment of exposure to food chemicals
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Exposure assessments are an integral part of risk assessment and are essential for protecting consumer health and factilitating international trade. The aim of this thesis was to explore the potential usefulness of a number ... -
The nutritional status of hospital patients and healthy elderly living in the community
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Protein-energy undernutrition is known to occur in patients on admission to hospital. In a prospective study of 594 sequential hospital admissions, we assessed the prevalence of undernutrition among patients on admission ... -
Virulent Mycobacterium tuberculosis Strains Evade Apoptosis of Infected Alveolar Macrophages
(2000)Human alveolar macrophages (AMφ) undergo apoptosis following infection with Mycobacterium tuberculosis in vitro. Apoptosis of cells infected with intracellular pathogens may benefit the host by eliminating a supportive ... -
Nutritional aspects of trans unsaturated fatty acids
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Dietary trans unsaturated fatty acids from hydrogenated vegetable and fish oils have been shown to raise plasma low density lipoprotein cholesterol and lower high density lipoprotein cholesterol levels at 10%, 6% and 3% ... -
Molecular aspects of human lipid metabolism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The postprandial lipaemic response refers to the changes in lipid and lipoprotein concentrations after consumption of a meal containing more than 15g of long-chain fatty acids. The magnitude and duration of the response ... -
Methodological issues in risk assessment of human exposure to artificial sweeteners in food
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The primary aim of this thesis is in estimating food chemical intakes with a specific interest in the area of intense sweeteners. To date all studies of intense sweeteners have been extremely detailed both in the estimate ... -
A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma
(Nature, 2001)The incidence of oesophageal adenocarcinoma is rising; to date, no susceptibility genes have been identified. p73, a novel p53 homologue, maps to chromosome 1p36, a region commonly deleted in oesophageal cancers. p73 shares ... -
Enternal nutrition in the community setting
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The practice of tube feeding patients outside the acute hospital setting has existed in Ireland for over a decade. Anecdotal evidence (mainly from hospital dietitians) suggested that the care services for these patients ... -
The study of periodicity of eating & public health nutrition issues
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)This thesis set out to provide an objective understanding of periodicity of eating in a group of free- living adults, by determining the temporal pattern of nutrient intake during eating occasions throughout the day. A ... -
Folic acid fortification of flour : determination of the level that gives rise to unmetabolised folic acid in serum
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)To prevent neural tube defects the Food and Drug Administration (FDA) implemented mandatory folic acid fortification o f all flour milled in the USA at a level 140μg/100g. The Centers for Disease Control (CDC) have proposed ... -
The folate catabolic process, its implications for folate requirement in humans and its antibacterial drug function
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)The one-carbon cycle, of which folate is the predominant constituent, is a major carrier of one-carbon units for biochemical synthesis, and is thought to be the sole mechanism of methyl-group transfer. It is involved both ...